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GDE1 Antibody
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NZC3 |
| Reactivity | Human |
| Predicted | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1,κ |
| Clone/Animal Names | 2021CT823.61.7 |
| Calculated MW | 37718 Da |
| Gene ID | 51573 |
|---|---|
| Other Names | Glycerophosphodiester phosphodiesterase 1, 3.1.4.44, Membrane-interacting protein of RGS16, RGS16-interacting membrane protein, GDE1, MIR16 |
| Target/Specificity | This GDE1 antibody is generated from a mouse immunized with a recombinant protein from the human region of human GDE1. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GDE1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GDE1 (HGNC:29644) |
|---|---|
| Function | Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol (By similarity). Hydrolyzes glycerophospho-N-acylethanolamines to N- acylethanolamines in the brain and participates in bioactive N- acylethanolamine biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N- oleoylethanolamine (an anorexic). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl- lysoPlsEt) to N-acylethanolamine. However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity (By similarity). Has little or no activity towards glycerophosphocholine (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q9JL55}; Multi-pass membrane protein. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9JL55}; Multi-pass membrane protein. Note=Perinuclear vesicles and cell membrane {ECO:0000250|UniProtKB:Q9JL55} |
| Tissue Location | Widely expressed.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Has glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity).
References
Zheng B.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:3999-4004(2000).
Duennebier F.F.,et al.Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
Loftus B.J.,et al.Genomics 60:295-308(1999).
Bachmann A.S.,et al.Gene 371:144-153(2006).
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